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Abstract <p>New derivatives of phosphonium salts (Z)-(2-(2-hydroxy-5-chlorphenyl)-2-phenylethenyl)octyldiphenylphosphonium chloride (PP8) and (2-hydroxybenzyl)dodecyldiphenylphosphonium chloride (6.5) were found to cause depolarization and permeabilization of the bacterial membrane. The ability of phosphonium salts to prevent the formation of <i>Staphylococcus</i> <i>aureus</i> biofilms and to disrupt them was demonstrated. Furthermore, the results demonstrated that the substances do not cause the development of resistance in the <i>S. aureus</i> strain. Finally, compound PP8 did not demonstrate mutagenic properties in the Ames test using strains of <i>Salmonella typhimurium</i> TA100 and <i>S. typhimurium</i> TA98.</p>

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Membranotropic Property and Antibiofilm Efficacy of Novel Phosphonium Derivatives Bearing Phenolic Moiety

  • 期刊论文

  • 发表日期：

    2025年8月6日

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  • A. P. Lyubina,
  • A. D. Voloshina,
  • S. K. Amerkhanova,
  • A. S. Sapunova,
  • D. A. Tatarinov,
  • V. F. Mironov

摘要

Abstract

New derivatives of phosphonium salts (Z)-(2-(2-hydroxy-5-chlorphenyl)-2-phenylethenyl)octyldiphenylphosphonium chloride (PP8) and (2-hydroxybenzyl)dodecyldiphenylphosphonium chloride (6.5) were found to cause depolarization and permeabilization of the bacterial membrane. The ability of phosphonium salts to prevent the formation of Staphylococcus aureus biofilms and to disrupt them was demonstrated. Furthermore, the results demonstrated that the substances do not cause the development of resistance in the S. aureus strain. Finally, compound PP8 did not demonstrate mutagenic properties in the Ames test using strains of Salmonella typhimurium TA100 and S. typhimurium TA98.