<b>Abstract</b>— <p>The composition, distribution, and grazing impact of mesozooplankton on phytoplankton in the area of the continental slope of the Laptev Sea and adjacent areas of the outer shelf and deep basin were studied. The data were obtained in August–September 2018 during cruise 72 of the R/V <i>Akademik Mstislav Keldysh</i> along two quasi-meridional transects. The zooplankton biomass (dry weight, DW) in the 0–bottom layer increased with depth from 3–5 g m^–2 on the shelf to 9–17 g m^–2 above the slope and 12–17 g m^–2 in deep-water areas. Over the shelf and slope, the proportion of <i>Calanus glacialis</i> in the total biomass was 80 and 45%, respectively, and it decreased to 32% in the deep-water area, while the proportion of <i>C. hyperboreus</i> increased to 39%. Contrary to the existing concept of an increased plankton concentration “belt” over the continental slope, no increase in the total zooplankton biomass was found in this area. The difference in the timing of the seasonal ice retreat was significant for the development of <i>C. glacialis</i> and had virtually no effect on the population dynamics of <i>C. hyperboreus</i> and <i>Metridia longa</i>. Daily rations when feeding on phytoplankton did not cover metabolic expenditures. Daily zooplankton grazing impact on phytoplankton of the size fraction &gt;3 μm was 0.4–2% of phytoplankton biomass on the shelf, 7–10% above the slope, and 1.5–6% in the deep-water area.</p>