Background <p>Occupational therapists strive to provide evidence-based cognitive rehabilitation for everyday functional activities in community-based rehabilitation.</p> Objective <p>In this study, we investigated the effectiveness of the Perceive, Recall, Plan and Perform (PRPP) Intervention in enhancing and maintaining task performance and cognitive strategy use during home-based rehabilitation for individuals with cognitive challenges following acquired brain injury.</p> Material and Methods <p>This study is a systematic replication of a single-case experimental designs using multiple baselines applied to three participants (67+ years old) undergoing nine PRPP Intervention sessions. The participants completed repeated measurements during baseline, intervention, post-intervention and follow-up phases. They were compared to their baseline phases, which was a control. Outcome measures included PRPP Assessment Stages 1 and 2. The analysis involved visual inspection of graphed data and the Tau-<i>U</i> method.</p> Results <p>The analysis revealed that all three participants showed positive changes in task mastery and effective cognitive strategy use after receiving PRPP Intervention, including maintenance immediately after intervention and 4 weeks later. A weighted Tau-U across participants indicated a very large effect (0.94) on task mastery.</p> Conclusions and Significance <p>The PRPP Intervention showed promising results in improving real-world task mastery and effective cognitive strategy use during home-based rehabilitation.</p> Trial reg.no <p>NCT05148247</p>