<p>Addressing health and social care disparities is an individualistic, organizational, and systemic endeavor. The root cause of disparities is collectively our individualistic unjust behaviours towards others, structural determinants, and systems of power, resulting in oppression of populations. The purpose of this paper is to propose <i>social intersectional compassion</i> framework for promoting social justice in health and social care. Drawing from intersectionality theory and literature about compassion, <i>social intersectional compassion</i> is defined as identifying, understanding, and alleviating individuals’ suffering through intentional and shared examination of their intersecting multiple identities and the impact of social systems and institutional structures on their well-being. The actionable ways to practice social intersectional compassion are: (a) understanding the meaning of suffering from individuals’ perspectives, (b) recognizing the root intersecting identities, structures, and processes contributing to suffering, (c) developing a relational connection with the individuals to attempt to alleviate suffering, and (d) embracing self-vulnerability to be affected by individuals’ suffering. The proposed framework of <i>social intersectional compassion</i> attempts to offer direction on how to alleviate individuals’ suffering and promote social justice and equity during individual interactions and when interacting with underserved communities in everyday life.</p>