Scholarlink

Background <p>In Germany, primary vaccination against invasive meningococcal disease (IMD) in young children was recommended against serogroup C (MenC) since 2005 and B (MenB) since 2024. Because of changes in the epidemiology of serogroups C and Y, we re-evaluated the MenC toddler vaccination, also considering scenarios of MenACWY vaccination.</p> Methods <p>We used a dynamic-transmission model of meningococcal carriage calibrated to national surveillance data for 10-year simulations. We compared MenC vaccination in toddlers with scenarios of (i) no MenC/MenACWY vaccination, (ii) MenACWY toddler vaccination, (iii) MenACWY primary adolescent vaccination, and (iv) combined MenACWY toddler plus adolescent booster vaccination. We compared prevented IMD cases, sequelae and deaths. In sensitivity analyses we varied key assumptions.</p> Results <p>The 243 (95%-uncertainty interval: 220–258) annual IMD cases with the MenC toddler vaccination increased by 2.9 (2.2–3.7) cases without MenC vaccination. Conversely, IMD cases were reduced by 2.4 (1.7–2.9), 3.6 (2.8–4.7), or 8.8 (7.8–9.8), with MenACWY toddler, primary adolescent, or combined toddler and adolescent vaccination, respectively. Preventing one IMD case required 210,000 (170,000–280,000) MenC or 120,000 (98,000–140,000) MenACWY toddler, 81,000 (71,000–91,000) MenACWY toddler and adolescent, and 51,000 (45,000–59,000) MenACWY primary adolescent vaccinations. Effectiveness of adolescent vaccination increased near-linearly with uptake. Longer simulations showed the potential for serogroup replacement resulting from MenACWY adolescent vaccination.</p> Conclusions <p>Continuing toddler vaccination with MenACWY (or MenC) keeps the IMD burden slightly lower than without toddler vaccination. Yet, MenACWY primary adolescent vaccination required the fewest doses per case prevented. Serogroup carriage requires up-to-date monitoring. This study informed the recently changed meningococcal vaccination recommendation in Germany.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Evaluation of the meningococcal C toddler vaccination and of introducing ACWY adolescent vaccination in Germany

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月7日

查看全文
  • Felix Günther,
  • Vanessa Piechotta,
  • Ole Wichmann,
  • Thomas Harder,
  • Alexander Dalpke,
  • Frank G. Sandmann

摘要

Background

In Germany, primary vaccination against invasive meningococcal disease (IMD) in young children was recommended against serogroup C (MenC) since 2005 and B (MenB) since 2024. Because of changes in the epidemiology of serogroups C and Y, we re-evaluated the MenC toddler vaccination, also considering scenarios of MenACWY vaccination.

Methods

We used a dynamic-transmission model of meningococcal carriage calibrated to national surveillance data for 10-year simulations. We compared MenC vaccination in toddlers with scenarios of (i) no MenC/MenACWY vaccination, (ii) MenACWY toddler vaccination, (iii) MenACWY primary adolescent vaccination, and (iv) combined MenACWY toddler plus adolescent booster vaccination. We compared prevented IMD cases, sequelae and deaths. In sensitivity analyses we varied key assumptions.

Results

The 243 (95%-uncertainty interval: 220–258) annual IMD cases with the MenC toddler vaccination increased by 2.9 (2.2–3.7) cases without MenC vaccination. Conversely, IMD cases were reduced by 2.4 (1.7–2.9), 3.6 (2.8–4.7), or 8.8 (7.8–9.8), with MenACWY toddler, primary adolescent, or combined toddler and adolescent vaccination, respectively. Preventing one IMD case required 210,000 (170,000–280,000) MenC or 120,000 (98,000–140,000) MenACWY toddler, 81,000 (71,000–91,000) MenACWY toddler and adolescent, and 51,000 (45,000–59,000) MenACWY primary adolescent vaccinations. Effectiveness of adolescent vaccination increased near-linearly with uptake. Longer simulations showed the potential for serogroup replacement resulting from MenACWY adolescent vaccination.

Conclusions

Continuing toddler vaccination with MenACWY (or MenC) keeps the IMD burden slightly lower than without toddler vaccination. Yet, MenACWY primary adolescent vaccination required the fewest doses per case prevented. Serogroup carriage requires up-to-date monitoring. This study informed the recently changed meningococcal vaccination recommendation in Germany.