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<p>Structural and functional assessment of microneedle tattoos requires real-time, high-resolution and high-sensitivity optical imaging at transdermal depths. Photoluminescence lifetime imaging offers a promising approach for bioimaging but relies on repetitive measurements or time-consuming image reconstruction, limiting the wide-field lifetime sensing of microneedle tattoos to ex vivo assessment. Here we report single-shot microneedle-encoded all-optical real-time upconversion lifetime mapping, which integrates dissolving microneedle arrays for on-object encoding, core–shell upconverting nanoparticles as transient emitters and an all-optical streak camera for single-shot lifetime mapping of microneedle tattoo luminescence. By leveraging the thermal coupling in upconversion luminescence, the system measures the microneedle tattoo temperature with 0.1 °C resolution at submillimetre spatial scales and video rates of up to 30 Hz. Implemented as in vivo thermo-dermoscopy, it enables the in situ diagnosis of early-stage micro-melanomas.</p>

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Single-shot microneedle-encoded upconversion lifetime mapping for real-time in vivo thermo-dermoscopy

  • 期刊论文

  • 发表日期：

    2026年5月20日

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  • Yingming Lai,
  • Alfonso Nieto Argüello,
  • Miao Liu,
  • Mathilde Soulez,
  • Miguel Marquez,
  • Fiorenzo Vetrone,
  • Sylvain Meloche,
  • Davide Brambilla,
  • Jinyang Liang

摘要

Structural and functional assessment of microneedle tattoos requires real-time, high-resolution and high-sensitivity optical imaging at transdermal depths. Photoluminescence lifetime imaging offers a promising approach for bioimaging but relies on repetitive measurements or time-consuming image reconstruction, limiting the wide-field lifetime sensing of microneedle tattoos to ex vivo assessment. Here we report single-shot microneedle-encoded all-optical real-time upconversion lifetime mapping, which integrates dissolving microneedle arrays for on-object encoding, core–shell upconverting nanoparticles as transient emitters and an all-optical streak camera for single-shot lifetime mapping of microneedle tattoo luminescence. By leveraging the thermal coupling in upconversion luminescence, the system measures the microneedle tattoo temperature with 0.1 °C resolution at submillimetre spatial scales and video rates of up to 30 Hz. Implemented as in vivo thermo-dermoscopy, it enables the in situ diagnosis of early-stage micro-melanomas.