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<p>The rational design of controlled carbon monoxide-releasing molecules (CORMs) represents a pivotal step toward harnessing the therapeutic benefits of CO. This review systematically analyzes the chemical design of organic CORMs, categorizing them into acyclic, monocyclic, and bridged systems. Key release mechanisms such as hydrolysis, cycloreversion, and radical- or photo-triggered pathways are detailed, with emphasis on stimuli-responsive designs enabling spatiotemporally controlled, biocompatible, and logic-gated CO delivery.</p>

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Chemical approaches to controlled carbon monoxide release: a focus on organic molecular donors

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月29日

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  • Wenwen Mu,
  • Xiaohua Chen,
  • Ziqian Zhang,
  • Youjun Yang,
  • Xuhong Qian,
  • Xiao Luo

摘要

The rational design of controlled carbon monoxide-releasing molecules (CORMs) represents a pivotal step toward harnessing the therapeutic benefits of CO. This review systematically analyzes the chemical design of organic CORMs, categorizing them into acyclic, monocyclic, and bridged systems. Key release mechanisms such as hydrolysis, cycloreversion, and radical- or photo-triggered pathways are detailed, with emphasis on stimuli-responsive designs enabling spatiotemporally controlled, biocompatible, and logic-gated CO delivery.