Scholarlink

<p>Alzheimer’s disease (AD) involves chronic neuroinflammation driven by tumor necrosis factor (TNF). XPro1595 selectively neutralizes pathological soluble TNF while preserving neuroprotective transmembrane TNF signaling. MINDFuL (clinicaltrials.gov NCT05318976, registration April 1st 2022) was a Phase 2, multicenter, randomized, double-blind, placebo-controlled, proof-of-concept study. Participants with Early AD and elevated inflammatory biomarkers received XPro1595 (1.0 mg/kg) or placebo for 24 weeks with Early Mild Alzheimer’s Cognitive Composite (EMACC) as the primary endpoint. A prospectively defined biomarker-enriched population included amyloid-positive participants with ≥2 inflammatory markers (ADi). The mITT population (<i>n</i> = 200) showed no difference in EMACC (<i>p</i> = 0.672). However, the ADi population (<i>n</i> = 100) showed signals across multiple clinical endpoints favoring XPro1595, including the EMACC (Cohen’s <i>d</i> = 0.27), Neuropsychiatric Inventory (<i>d</i> = −0.23), particularly the subfactor agitation/hyperactivity (d = −0.37), and the Goal Attainment Scale (<i>d</i> = 0.18). Accordingly, in ADi, XPro1595 attenuated plasma pTau217 (<i>d</i> = −0.18) and GFAP (<i>d</i> = −0.19). Many effect sizes were larger in participants with higher drug exposure. Notably, no amyloid-related imaging abnormalities (ARIA) were observed. While XPro1595 did not meet the primary endpoint in mITT, in ADi consistent directional patterns favoring XPro1595 across cognitive and neuropsychiatric outcomes were observed. These findings support XPro1595 as an interesting therapeutic for persons with AD and elevated inflammatory burden.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

XPro1595 in early Alzheimer’s disease with inflammation: results from the phase 2 MINDFuL trial

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月13日

查看全文
  • Judith Jaeger,
  • Kim A. Staats,
  • Sarah Barnum,
  • Parris Pope,
  • Lisle Kingery,
  • Melanie Buitendyk,
  • Sharon Cohen,
  • Malú Gámez Tansey,
  • Raymond J. Tesi,
  • Christopher J. Barnum

摘要

Alzheimer’s disease (AD) involves chronic neuroinflammation driven by tumor necrosis factor (TNF). XPro1595 selectively neutralizes pathological soluble TNF while preserving neuroprotective transmembrane TNF signaling. MINDFuL (clinicaltrials.gov NCT05318976, registration April 1st 2022) was a Phase 2, multicenter, randomized, double-blind, placebo-controlled, proof-of-concept study. Participants with Early AD and elevated inflammatory biomarkers received XPro1595 (1.0 mg/kg) or placebo for 24 weeks with Early Mild Alzheimer’s Cognitive Composite (EMACC) as the primary endpoint. A prospectively defined biomarker-enriched population included amyloid-positive participants with ≥2 inflammatory markers (ADi). The mITT population (n = 200) showed no difference in EMACC (p = 0.672). However, the ADi population (n = 100) showed signals across multiple clinical endpoints favoring XPro1595, including the EMACC (Cohen’s d = 0.27), Neuropsychiatric Inventory (d = −0.23), particularly the subfactor agitation/hyperactivity (d = −0.37), and the Goal Attainment Scale (d = 0.18). Accordingly, in ADi, XPro1595 attenuated plasma pTau217 (d = −0.18) and GFAP (d = −0.19). Many effect sizes were larger in participants with higher drug exposure. Notably, no amyloid-related imaging abnormalities (ARIA) were observed. While XPro1595 did not meet the primary endpoint in mITT, in ADi consistent directional patterns favoring XPro1595 across cognitive and neuropsychiatric outcomes were observed. These findings support XPro1595 as an interesting therapeutic for persons with AD and elevated inflammatory burden.