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<p>Only few studies of Allostatic Load (AL) have been conducted in Latin-American cohorts. Here, we replicated a recently proposed comprehensive algorithm (ALCS) to derive an AL index in a Chilean cohort of cognitive healthy adults. Using data from the GERO cohort (<i>n</i> = 166, age 76.92 ± 5.07 years) we generated an ALCS AL index through and compared for model fit with a purely sample distribution l algorithm (ALES). ALCS largely improved when some clinical values were corrected for ages ≥65, although failed to achieve sufficient goodness of fit. A final inclusion of an additional inflammatory biomarker resulted in further improvement of ALES, but not on ALCS. The ALES algorithm, which do not include clinical thresholds, achieved satisfactory fit after correcting for sample disparities between sexes. This suggests the need to consider the suitability of clinical thresholds developed in younger populations and the need to develop specific thresholds for assessing older adults.</p>

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Allostatic load calculation in a Chilean older-adults cohort reveals the need for age-specific clinical thresholds

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月25日

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  • Ingrid Buller-Peralta,
  • Graciela Muniz-Terrera,
  • Patricia Lillo,
  • Patricio Riquelme,
  • Michele Demanet,
  • Rodrigo Saguez,
  • Francisca Damm,
  • Felipe Salech,
  • Christian Gonzalez-Billault,
  • Felipe A. Court,
  • Daniela Thumala,
  • Andrea Slachevsky

摘要

Only few studies of Allostatic Load (AL) have been conducted in Latin-American cohorts. Here, we replicated a recently proposed comprehensive algorithm (ALCS) to derive an AL index in a Chilean cohort of cognitive healthy adults. Using data from the GERO cohort (n = 166, age 76.92 ± 5.07 years) we generated an ALCS AL index through and compared for model fit with a purely sample distribution l algorithm (ALES). ALCS largely improved when some clinical values were corrected for ages ≥65, although failed to achieve sufficient goodness of fit. A final inclusion of an additional inflammatory biomarker resulted in further improvement of ALES, but not on ALCS. The ALES algorithm, which do not include clinical thresholds, achieved satisfactory fit after correcting for sample disparities between sexes. This suggests the need to consider the suitability of clinical thresholds developed in younger populations and the need to develop specific thresholds for assessing older adults.