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<p>Clonal hematopoiesis of indeterminate potential (CHIP) has been associated with Alzheimer’s disease (AD) protection. Both entities have increased prevalence with age, similar molecular mechanisms based on myeloid lineage, and their preclinical nature allows for screening before symptomatic disease. We propose a synergistic model that allows us to identify the key moments in the natural history of AD by including CHIP, AD biomarkers and clinical outcomes.</p>

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Clonal hematopoiesis as the intersection between genetics and resilience in Alzheimer’s disease

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年6月19日

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  • Juan López-de-Mesa-Aragón,
  • Cristina Silva-Buriticá,
  • Salomón Salazar-Londoño

摘要

Clonal hematopoiesis of indeterminate potential (CHIP) has been associated with Alzheimer’s disease (AD) protection. Both entities have increased prevalence with age, similar molecular mechanisms based on myeloid lineage, and their preclinical nature allows for screening before symptomatic disease. We propose a synergistic model that allows us to identify the key moments in the natural history of AD by including CHIP, AD biomarkers and clinical outcomes.