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<p>The human oral microbiota is a community of microorganisms that reside in the oral cavity, including lingual, buccal, and saliva, each niche with a distinct microbial composition. Alterations in oral microbiota have been associated with an increased risk of Alzheimer’s disease (AD). This study used data from 143 older adults in the MIND trial to evaluate the association between oral microbiome and cognitive function. Oral niche-specific differences (saliva, buccal, and lingual), as well as the microbiome composition differences (α and β diversity), were associated with cognitive function. A lower abundance of <i>Gemella</i> and a higher abundance of anaerobic pro-inflammatory bacteria (e.g., <i>Parvimonas</i>, <i>Treponema</i>, <i>Dialister</i>) were linked to a lower Cognitive Z Score. <i>Porphyromonas</i>, previously linked to AD, was not associated with cognition. The outcomes suggest that oral microbiota may be a biomarker for cognitive function. Further research is required to assess whether oral microbiota-directed strategies can positively impact cognitive decline.</p>

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Oral microbiome brain axis and cognitive performance in older adults

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年4月7日

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  • Darbaz Adnan,
  • Phillip A. Engen,
  • Michelle Villanueva,
  • Shohreh Raeisi,
  • Vivian Ramirez,
  • Ankur Naqib,
  • Stefan J. Green,
  • Faraz Bishehsari,
  • Lisa L. Barnes,
  • Ali Keshavarzian,
  • Klodian Dhana,
  • Robin M. Voigt

摘要

The human oral microbiota is a community of microorganisms that reside in the oral cavity, including lingual, buccal, and saliva, each niche with a distinct microbial composition. Alterations in oral microbiota have been associated with an increased risk of Alzheimer’s disease (AD). This study used data from 143 older adults in the MIND trial to evaluate the association between oral microbiome and cognitive function. Oral niche-specific differences (saliva, buccal, and lingual), as well as the microbiome composition differences (α and β diversity), were associated with cognitive function. A lower abundance of Gemella and a higher abundance of anaerobic pro-inflammatory bacteria (e.g., Parvimonas, Treponema, Dialister) were linked to a lower Cognitive Z Score. Porphyromonas, previously linked to AD, was not associated with cognition. The outcomes suggest that oral microbiota may be a biomarker for cognitive function. Further research is required to assess whether oral microbiota-directed strategies can positively impact cognitive decline.