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<p>Despite the prevalence of neuropathic pain and the opioid crisis, there has been little progress in the development of non-opioid alternative therapies. Protein kinases orchestrate multiple key pathophysiological events in the progression of pain signaling pathways. This review highlights druggable kinases and the associated scaffolds as well as molecular modalities to reverse mechanical allodynia and thermal hyperalgesia in neuropathy models whether preclinically or clinically.</p>

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Targeting druggable kinases in neuropathic pain

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月21日

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  • Harrison Benson,
  • Komalpreet Kaur,
  • Mahmoud Salama Ahmed

摘要

Despite the prevalence of neuropathic pain and the opioid crisis, there has been little progress in the development of non-opioid alternative therapies. Protein kinases orchestrate multiple key pathophysiological events in the progression of pain signaling pathways. This review highlights druggable kinases and the associated scaffolds as well as molecular modalities to reverse mechanical allodynia and thermal hyperalgesia in neuropathy models whether preclinically or clinically.