Scholarlink

<p>Microphysiological models recapitulating complex vasculature have enabled in vitro evaluation of intricate cellular crosstalk and microenvironmental mechanical cues and stressors. Here, we present a comprehensive review of time and architecture as two under-explored facets required for physiological mimetic vascular models. We conclude with our perspective that incorporating longevity and architecture will improve complex vascular modeling and provide a platform to support chronic disease modeling, personalized medicine, drug testing, and tissue engineering.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Time and architecture: the next two dimensions of microphysiological systems

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月25日

查看全文
  • Rashmi Pandey,
  • Jennifer Lee,
  • Anahita Mojiri,
  • John P. Cooke,
  • Abhishek Jain

摘要

Microphysiological models recapitulating complex vasculature have enabled in vitro evaluation of intricate cellular crosstalk and microenvironmental mechanical cues and stressors. Here, we present a comprehensive review of time and architecture as two under-explored facets required for physiological mimetic vascular models. We conclude with our perspective that incorporating longevity and architecture will improve complex vascular modeling and provide a platform to support chronic disease modeling, personalized medicine, drug testing, and tissue engineering.