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<p>Engineered bacterial therapeutics are emerging as promising candidates for the treatment of solid cancers. However, despite effectively reducing tumour burden in different pre-clinical models, these “smart bugs” are yet to convincingly translate this efficacy to cancer treatment in humans. Here, we highlight key features of in vitro co-culture methods and how they can be used to investigate bacterial behaviour and guide the rational engineering of more effective anti-cancer bacterial therapeutics.</p>

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Use of in vitro co-culture models to inform bacterial engineering for the treatment of solid tumours

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月23日

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  • Sara Foschini,
  • Josephine A. Wright,
  • Susan L. Woods,
  • Rebekah de Nys

摘要

Engineered bacterial therapeutics are emerging as promising candidates for the treatment of solid cancers. However, despite effectively reducing tumour burden in different pre-clinical models, these “smart bugs” are yet to convincingly translate this efficacy to cancer treatment in humans. Here, we highlight key features of in vitro co-culture methods and how they can be used to investigate bacterial behaviour and guide the rational engineering of more effective anti-cancer bacterial therapeutics.