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<p>Osteoarthritis, a complex genetic disease, involves disrupted joint homeostasis driven by catabolic and inflammatory processes. Traditional therapies offer limited success. This review explores nucleic acid-based therapeutics—siRNA, miRNA, and mRNA—as a promising strategy for restoring balance by modulating gene expression. Nanoplatforms enable precise delivery of these molecules, offering potential for disease-modifying interventions. Emphasis is placed on advancing RNA therapies tailored to the disease stage for effective disease management.</p>

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Nucleic acid-based therapeutics to restore joint homeostasis in age-related and post-traumatic arthritis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月27日

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  • Muhammad Farooq Rai,
  • Christine TN Pham,
  • Kirk Hou,
  • Samuel A. Wickline,
  • Hua Pan

摘要

Osteoarthritis, a complex genetic disease, involves disrupted joint homeostasis driven by catabolic and inflammatory processes. Traditional therapies offer limited success. This review explores nucleic acid-based therapeutics—siRNA, miRNA, and mRNA—as a promising strategy for restoring balance by modulating gene expression. Nanoplatforms enable precise delivery of these molecules, offering potential for disease-modifying interventions. Emphasis is placed on advancing RNA therapies tailored to the disease stage for effective disease management.