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<p>Myocardial infarction and heart failure remain leading causes of mortality worldwide. Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) represent a promising approach to regenerating damaged myocardium and restoring cardiac function. This review highlights advancements in hPSC-CM differentiation, scale-up, and clinical-grade manufacturing; delivery approaches; and insights from preclinical and clinical studies. We also examine mechanisms of repair, key challenges and mitigation strategies, and future directions to advance hPSC-CM therapies toward clinical translation.</p>

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Progress and challenges in transplantation of human pluripotent stem cell derived cardiomyocytes for cardiac therapy

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月7日

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  • Jacelyn D. Bain,
  • Ryan W. Barrs,
  • Ying Mei

摘要

Myocardial infarction and heart failure remain leading causes of mortality worldwide. Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) represent a promising approach to regenerating damaged myocardium and restoring cardiac function. This review highlights advancements in hPSC-CM differentiation, scale-up, and clinical-grade manufacturing; delivery approaches; and insights from preclinical and clinical studies. We also examine mechanisms of repair, key challenges and mitigation strategies, and future directions to advance hPSC-CM therapies toward clinical translation.