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<p>Cardiac spheroids (CSs) offer valuable insights into the fundamental aspects of cardiac biology as they model molecular, cellular, and extracellular features typical of the myocardium. This review introduces current engineering methods for CS generation and their applications. Commonly referred to as “mini hearts”, their applications include disease modelling, drug and toxicity screening, and personalised therapeutics in cardiac regenerative medicine.</p>

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Generation and applications of cardiac spheroids

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年6月10日

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  • Dana Idais,
  • Christopher D. Roche,
  • Georgia Kalogianni,
  • Liudmila Polonchuk,
  • Carmine Gentile

摘要

Cardiac spheroids (CSs) offer valuable insights into the fundamental aspects of cardiac biology as they model molecular, cellular, and extracellular features typical of the myocardium. This review introduces current engineering methods for CS generation and their applications. Commonly referred to as “mini hearts”, their applications include disease modelling, drug and toxicity screening, and personalised therapeutics in cardiac regenerative medicine.