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<p>Ultrasound contrast agents (UCAs) allow to assess brain perfusion via contrast-enhanced ultrasound (CEUS) imaging and to perform ultrasound-based therapies such as blood brain barrier opening. Currently, the heterogeneous distribution of the UCAs within physiological and pathological structures is neglected to dynamically fine-tune the treatment schemes. Since microbubbles are pure intravascular agents, we hypothesize that their distribution can be correlated with Dynamic-Susceptibility-Contrast (DSC) MRI. Pre-operative DSC-MRI and intra-operative CEUS imaging were performed in 31 patients undergoing elective brain tumor resection. At qualitative comparison, CEUS and DSC-MRI showed superimposable anatomical structures and lesion perfusion features in all cases. Quantitative analysis revealed no correlation between CEUS and DSC for MTT, moderate correlation for TTP, and negative correlation for nAUC with DSC-CBV. Our results indicate that DSC-MRI perfusion patterns demonstrate both qualitative and quantitative correlation with CEUS and can be used as a non-invasive biomarker for MBs’ distribution in the human brain.</p>

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Cerebral microbubble distribution correlation between preoperative perfusion MRI and intraoperative contrast enhanced ultrasound

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月4日

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  • Fabio M. Doniselli,
  • Riccardo Ciocca,
  • Domenico Aquino,
  • Marina Grisoli,
  • Massimiliano Del Bene,
  • Stefania Ferraro,
  • Giovanni Durando,
  • Luca Raspagliesi,
  • Frederic Padilla,
  • Luca Maria Sconfienza,
  • Francesco DiMeco,
  • Francesco Prada

摘要

Ultrasound contrast agents (UCAs) allow to assess brain perfusion via contrast-enhanced ultrasound (CEUS) imaging and to perform ultrasound-based therapies such as blood brain barrier opening. Currently, the heterogeneous distribution of the UCAs within physiological and pathological structures is neglected to dynamically fine-tune the treatment schemes. Since microbubbles are pure intravascular agents, we hypothesize that their distribution can be correlated with Dynamic-Susceptibility-Contrast (DSC) MRI. Pre-operative DSC-MRI and intra-operative CEUS imaging were performed in 31 patients undergoing elective brain tumor resection. At qualitative comparison, CEUS and DSC-MRI showed superimposable anatomical structures and lesion perfusion features in all cases. Quantitative analysis revealed no correlation between CEUS and DSC for MTT, moderate correlation for TTP, and negative correlation for nAUC with DSC-CBV. Our results indicate that DSC-MRI perfusion patterns demonstrate both qualitative and quantitative correlation with CEUS and can be used as a non-invasive biomarker for MBs’ distribution in the human brain.