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<p>Focused-ultrasound (FUS) in conjunction with microbubbles contrast agent is a non-invasive methods to induce transient blood brain barrier (BBB) disruption. This review aims to provide an overview of the imaging strategies (magnetic resonance imaging, positron emission tomography, and ultrasound imaging) used in parallel with FUS-induced BBB opening in pre-clinical and clinical studies to ensure the safety and efficacy of the technique.</p>

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Imaging strategies to assess efficacy and safety of ultrasound-induced blood-brain barrier opening

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月1日

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  • Gwenaël Pagé,
  • Anthony Novell,
  • Benoît Larrat

摘要

Focused-ultrasound (FUS) in conjunction with microbubbles contrast agent is a non-invasive methods to induce transient blood brain barrier (BBB) disruption. This review aims to provide an overview of the imaging strategies (magnetic resonance imaging, positron emission tomography, and ultrasound imaging) used in parallel with FUS-induced BBB opening in pre-clinical and clinical studies to ensure the safety and efficacy of the technique.