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<p>The handling of individual cells is the basis for single-cell studies. Richer modes, wider ranges, and higher resolution are the goals that various microgripper techniques are chasing, yet few techniques satisfy these metrics. Herein, we propose a versatile microgripper technology, which uses hydrodynamics and acoustics to peel and trap cells as a programmable microgripper. We choose a mini-packaged GHz resonator to generate micro vortices, inducing up to 2500 Pa shear stress on a microscale region. Controllable detachment based on spatial position and adhesion status, three-dimensional movement, and the assembly of individual cells is achieved by integrating with the displacement stage. This noncontact and label-free technology provides a user-friendly strategy for single-cell manipulation in Petri dish, which conforms to the preferences of researchers and realizes flexible operations that traditionally require multiple platforms and promises to provide an automated solution for a variety of biological and pharmaceutical research.</p>

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Acoustic streaming microgripper for programmable three-dimensional manipulation of single cells

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月1日

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  • Yang Yang,
  • Ke Jin,
  • Hang Qi,
  • Wei Wei,
  • You Zhou,
  • Chongling Sun,
  • Xuejiao Chen,
  • Yanyan Wang,
  • Luke P. Lee,
  • Xuexin Duan

摘要

The handling of individual cells is the basis for single-cell studies. Richer modes, wider ranges, and higher resolution are the goals that various microgripper techniques are chasing, yet few techniques satisfy these metrics. Herein, we propose a versatile microgripper technology, which uses hydrodynamics and acoustics to peel and trap cells as a programmable microgripper. We choose a mini-packaged GHz resonator to generate micro vortices, inducing up to 2500 Pa shear stress on a microscale region. Controllable detachment based on spatial position and adhesion status, three-dimensional movement, and the assembly of individual cells is achieved by integrating with the displacement stage. This noncontact and label-free technology provides a user-friendly strategy for single-cell manipulation in Petri dish, which conforms to the preferences of researchers and realizes flexible operations that traditionally require multiple platforms and promises to provide an automated solution for a variety of biological and pharmaceutical research.