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<p>The human liver carries out critical functions in metabolism and immune regulation. Replicating its extracellular matrix landscape is central to tissue and disease modeling. The dominance of Matrigel<sup>®</sup> in tissue culture and organoid formation is increasingly being rivaled by decellularized liver extracellular matrix-derived hydrogels as promising alternatives that preserve the inherent complexity of their natural counterparts, thereby advancing hepatic organoid formation and maturation as well as high-throughput drug screening.</p>

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Engineering extracellular matrix-based liver hydrogels as advanced bio-mimetic platforms

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月20日

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  • Jonas K. Wieland,
  • Marie Weinhart,
  • Björn Papke,
  • Josef A. Käs,
  • Kilian Roth,
  • Ingolf Sack,
  • Johann Pratschke,
  • Igor M. Sauer,
  • Karl H. Hillebrandt,
  • Assal Daneshgar

摘要

The human liver carries out critical functions in metabolism and immune regulation. Replicating its extracellular matrix landscape is central to tissue and disease modeling. The dominance of Matrigel® in tissue culture and organoid formation is increasingly being rivaled by decellularized liver extracellular matrix-derived hydrogels as promising alternatives that preserve the inherent complexity of their natural counterparts, thereby advancing hepatic organoid formation and maturation as well as high-throughput drug screening.