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<p>Poly(ADP-ribose) polymerases (PARPs) comprise a family of 17 enzymes were initially identified for their essential roles in DNA damage repair and maintenance of genomic stability. Emerging evidence has unveiled their critical involvement in various liver diseases, including viral hepatitis, metabolic disorders, fibrosis, and hepatocellular carcinoma. This review summarizes PARPs’ roles in liver diseases and the evidence supporting PARP inhibitor therapy.</p>

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PARPs in liver diseases

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月3日

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  • Jiaxin Xia,
  • Xiao Tang,
  • Qihua Zhu,
  • Yizhu Xu

摘要

Poly(ADP-ribose) polymerases (PARPs) comprise a family of 17 enzymes were initially identified for their essential roles in DNA damage repair and maintenance of genomic stability. Emerging evidence has unveiled their critical involvement in various liver diseases, including viral hepatitis, metabolic disorders, fibrosis, and hepatocellular carcinoma. This review summarizes PARPs’ roles in liver diseases and the evidence supporting PARP inhibitor therapy.