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<p>Irritable bowel syndrome (IBS) is subtyped based on bowel habits. However, a more comprehensive subgrouping based on combined gastrointestinal (GI), non-GI somatic, and psychological symptom profiles has been proposed. This study aimed to validate this new approach, including the exploration of differences in patient-reported outcomes and gut physiology across subgroups. Six subgroups were identified based on Gaussian mixture model analysis including 760 patients with IBS: diarrhea with low or high comorbidity burden, constipation with low or high comorbidity burden, overall mild severity, and mixed GI symptoms with high comorbidity burden. IBS symptoms, GI-specific anxiety, and fatigue were more severe, and quality of life was lower in those with high comorbidity burden. Oro-anal transit time differed between the diarrhea and constipation subgroups, but only between those with low comorbidity burden. Our data revealed a relevance for the proposed novel subgrouping strategies, including links to distinct pathophysiological mechanisms.</p>

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Validation of novel irritable bowel syndrome subgroups based on gastrointestinal and extraintestinal symptom profiles

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月17日

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  • Tom van Gils,
  • Joost P. Algera,
  • Irina Midenfjord,
  • Wilhelm Sjöland,
  • Hans Törnblom,
  • Magnus Simrén

摘要

Irritable bowel syndrome (IBS) is subtyped based on bowel habits. However, a more comprehensive subgrouping based on combined gastrointestinal (GI), non-GI somatic, and psychological symptom profiles has been proposed. This study aimed to validate this new approach, including the exploration of differences in patient-reported outcomes and gut physiology across subgroups. Six subgroups were identified based on Gaussian mixture model analysis including 760 patients with IBS: diarrhea with low or high comorbidity burden, constipation with low or high comorbidity burden, overall mild severity, and mixed GI symptoms with high comorbidity burden. IBS symptoms, GI-specific anxiety, and fatigue were more severe, and quality of life was lower in those with high comorbidity burden. Oro-anal transit time differed between the diarrhea and constipation subgroups, but only between those with low comorbidity burden. Our data revealed a relevance for the proposed novel subgrouping strategies, including links to distinct pathophysiological mechanisms.