Scholarlink

<p>Regulatory T cells (Tregs) suppress immune responses through multiple mechanisms, including contact-dependent removal of pMHCII and costimulatory ligands from antigen-presenting cells via trogocytosis and trans-endocytosis. These pathways require membrane deformation, receptor engagement, and vesicular trafficking. We propose that Treg efficiency in these processes is shaped by cellular mechanics—particularly membrane tension and actin organization—yielding a distinct biophysical signature for antigen-specific suppression.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Mechanobiology of regulatory T cells: how cellular mechanics shape immune suppression

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月17日

查看全文
  • Valeria I. Arteaga-Muñiz,
  • Vishal Singh,
  • Billur Akkaya,
  • Cӧmert Kural

摘要

Regulatory T cells (Tregs) suppress immune responses through multiple mechanisms, including contact-dependent removal of pMHCII and costimulatory ligands from antigen-presenting cells via trogocytosis and trans-endocytosis. These pathways require membrane deformation, receptor engagement, and vesicular trafficking. We propose that Treg efficiency in these processes is shaped by cellular mechanics—particularly membrane tension and actin organization—yielding a distinct biophysical signature for antigen-specific suppression.