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<p>Biological systems are complex networks where measurable functions emerge from interactions among thousands of components. Many studies aim to link biological function with molecular elements, yet quantifying their contributions simultaneously remains challenging, especially at the single-cell level. We propose a machine-learning approach that integrates faceted data subsets to reconstruct a complete view of the system using conditional distributions. We develop both polynomial regression and neural network models, validated with two examples: a mechanical spring network under external forces and an 8-dimensional biological network involving the senescence marker P53, using single-cell data. Our results demonstrate successful system reconstruction from partial datasets, with predictive accuracy improving as more variables are measured. This approach offers a systematic method to integrate fragmented experimental data, enabling unbiased and holistic modeling of complex biological functions.</p>

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Unifying fragmented perspectives with additive deep learning for high-dimensional models from partial faceted datasets

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年2月24日

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  • Yufei Wu,
  • Pei-Hsun Wu,
  • Allison Chambliss,
  • Denis Wirtz,
  • Sean X. Sun

摘要

Biological systems are complex networks where measurable functions emerge from interactions among thousands of components. Many studies aim to link biological function with molecular elements, yet quantifying their contributions simultaneously remains challenging, especially at the single-cell level. We propose a machine-learning approach that integrates faceted data subsets to reconstruct a complete view of the system using conditional distributions. We develop both polynomial regression and neural network models, validated with two examples: a mechanical spring network under external forces and an 8-dimensional biological network involving the senescence marker P53, using single-cell data. Our results demonstrate successful system reconstruction from partial datasets, with predictive accuracy improving as more variables are measured. This approach offers a systematic method to integrate fragmented experimental data, enabling unbiased and holistic modeling of complex biological functions.