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<p>Shared neoantigens and cancer-related biomarkers are suitable biomolecules with the potential to pursue equitable cancer early diagnosis and immunotherapy at large scale. This review outlines the current repertoire on shared neoantigens and critically assesses the landscape of analytical platforms for their profiling, with a focus on their translation from laboratory-scale systems to emerging single-molecule detection technologies, paving the way toward point-of-care testing as the ultimate ultrasensitive analytical strategy with significant scalability.</p>

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Prioritizing shared neoantigens profiling across analytical platforms for an inclusive cancer immunotherapy: from bench to the point-of-care frontier

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月30日

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  • Erika Castrignanò,
  • Eleonora Macchia,
  • Valentina Morciano,
  • Paolo Bollella,
  • Alessandra Costantino,
  • Valentina Mongelli,
  • Lucia Sarcina,
  • Ilaria Iacobellis,
  • Mariapia Caputo,
  • Francesco Leonetti,
  • Luisa Torsi

摘要

Shared neoantigens and cancer-related biomarkers are suitable biomolecules with the potential to pursue equitable cancer early diagnosis and immunotherapy at large scale. This review outlines the current repertoire on shared neoantigens and critically assesses the landscape of analytical platforms for their profiling, with a focus on their translation from laboratory-scale systems to emerging single-molecule detection technologies, paving the way toward point-of-care testing as the ultimate ultrasensitive analytical strategy with significant scalability.