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<p>Annually, over 10 million patients undergo high-risk invasive intracranial monitoring, facing risks of infection and secondary surgeries. Injectable ultrasonic metagels, wireless, biodegradable sensors with air-column matrices for multiparameter (pressure, temperature, pH, flow) ultrasound readout, are delivered via 5.8 mm burr-hole/22 G needle (avoiding ≥10 mm craniotomy), enabling ambulatory monitoring. Biodegradation eliminates removal surgery, addressing biocompatibility, fidelity, and deployability. However, unresolved degradation kinetics, motion artifact, and deep-tissue signal require resolution for further clinical translation.</p>

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Injectable ultrasonic metagels for intracranial monitoring

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月3日

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  • Yuchun Wang,
  • Minyan Ge,
  • Ru Wang,
  • Yinghao Zhu,
  • Shumao Xu

摘要

Annually, over 10 million patients undergo high-risk invasive intracranial monitoring, facing risks of infection and secondary surgeries. Injectable ultrasonic metagels, wireless, biodegradable sensors with air-column matrices for multiparameter (pressure, temperature, pH, flow) ultrasound readout, are delivered via 5.8 mm burr-hole/22 G needle (avoiding ≥10 mm craniotomy), enabling ambulatory monitoring. Biodegradation eliminates removal surgery, addressing biocompatibility, fidelity, and deployability. However, unresolved degradation kinetics, motion artifact, and deep-tissue signal require resolution for further clinical translation.