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<p>Systemic semilunar valve replacement in neonates and infants is rare and usually a last resort. We analyzed Pediatric Cardiac Care Consortium data for patients undergoing Ross, aortic valve replacement (AVR), or truncal valve replacement (TVR) from 1982–2011 across 35 centers, with mortality tracked via the US National Death Index through 2022. Among 167 patients, in-hospital mortality was 23% for Ross, 49% for AVR, and 52% for TVR. Twenty-five–year survival was 59%, 29%, and 41%, respectively. Neonatal age (vs. infant) was associated with increased in-hospital and long-term mortality (OR 2.5, 3.9, respectively), while higher surgical weight was protective (OR 0.67, 0.61 per kg, respectively). The earlier surgical era was associated with higher in-hospital mortality (OR 3.4). AVR had over threefold in-hospital and long-term mortality (OR 3.2, 3.4, respectively). These results highlight the historically high risk of systemic semilunar valve replacement in this population and the need for innovative surgical approaches.</p>

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Short- and long-term outcomes of systemic semilunar valve replacement in neonates and infants

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月23日

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  • Abdelrahman Masri,
  • Caroline Yunhua Shi,
  • Brent Winemiller,
  • Haya Alsarrawi,
  • Lazaros K. Kochilas,
  • Brian Reemtsen,
  • Amna Qasim,
  • Taufiek Konrad Rajab

摘要

Systemic semilunar valve replacement in neonates and infants is rare and usually a last resort. We analyzed Pediatric Cardiac Care Consortium data for patients undergoing Ross, aortic valve replacement (AVR), or truncal valve replacement (TVR) from 1982–2011 across 35 centers, with mortality tracked via the US National Death Index through 2022. Among 167 patients, in-hospital mortality was 23% for Ross, 49% for AVR, and 52% for TVR. Twenty-five–year survival was 59%, 29%, and 41%, respectively. Neonatal age (vs. infant) was associated with increased in-hospital and long-term mortality (OR 2.5, 3.9, respectively), while higher surgical weight was protective (OR 0.67, 0.61 per kg, respectively). The earlier surgical era was associated with higher in-hospital mortality (OR 3.4). AVR had over threefold in-hospital and long-term mortality (OR 3.2, 3.4, respectively). These results highlight the historically high risk of systemic semilunar valve replacement in this population and the need for innovative surgical approaches.