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<p>Coronary biomechanics including structural wall stress and strain on the vessel wall and flow wall shear stress on the endothelial surface play a vital role in plaque progression, rupture and erosion. This review summarizes recent advances in coronary intravascular imaging, image-based biomechanical modeling, and their applications in investigating possible biomechanical mechanisms of plaque rupture and erosion, and developing interventional therapies targeting unfavorable mechanical conditions for personalized treatment and precision medicine.</p>

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Role of biomechanical factors in plaque rupture and erosion: insight from intravascular imaging based computational modeling

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年4月16日

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  • Liang Wang,
  • Yanwen Zhu,
  • Chen Zhao,
  • Akiko Maehara,
  • Rui Lv,
  • Xiaoya Guo,
  • Mingming Yang,
  • Gary S. Mintz,
  • Dalin Tang,
  • Haibo Jia,
  • Bo Yu

摘要

Coronary biomechanics including structural wall stress and strain on the vessel wall and flow wall shear stress on the endothelial surface play a vital role in plaque progression, rupture and erosion. This review summarizes recent advances in coronary intravascular imaging, image-based biomechanical modeling, and their applications in investigating possible biomechanical mechanisms of plaque rupture and erosion, and developing interventional therapies targeting unfavorable mechanical conditions for personalized treatment and precision medicine.