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<p>Skeletal muscle harbors cell-autonomous circadian clock that is implicated in muscle as well as systemic metabolic and physiological functions. Emerging evidence highlights how the muscle clock integrates time-signals to regulate physical activity. Physical activity imposes recurrent and temporally structured physiological and metabolic perturbations. Here we discuss the literature and propose that the muscle clock is well-positioned to execute anticipatory regulation by engaging metabolic programs in advance of predictable muscle demands.</p>

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Timing the strain: skeletal muscle clock as regulator of physical activity

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月29日

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  • Ippei Kawano,
  • Gad Asher

摘要

Skeletal muscle harbors cell-autonomous circadian clock that is implicated in muscle as well as systemic metabolic and physiological functions. Emerging evidence highlights how the muscle clock integrates time-signals to regulate physical activity. Physical activity imposes recurrent and temporally structured physiological and metabolic perturbations. Here we discuss the literature and propose that the muscle clock is well-positioned to execute anticipatory regulation by engaging metabolic programs in advance of predictable muscle demands.