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<p>Sleep onset is an unstable transition whose microstructure may distinguish clinical phenotypes. Using Hori 4-second microstaging in patients with narcolepsy type 1, idiopathic REM sleep behaviour disorder, NREM parasomnia and an exploratory fibromyalgia cohort, each with matched controls (<i>n</i> = 48 pairs), we quantified timing, entropy, hemispheric laterality and sequence ordering. Narcolepsy showed compressed, irregular onset, fibromyalgia prolonged divergent onset, and the remaining groups near-normative trajectories, suggesting disorder-specific signatures of arousal instability.</p>

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Disordered descent into sleep: microstructural divergence across arousal-linked conditions

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月26日

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  • Nazanin Biabani,
  • Adam Birdseye,
  • Valentina Gnoni,
  • Riva Tauman,
  • Katarina Ilic,
  • Panagis Drakatos,
  • Alexander Nesbitt,
  • Monica Puligheddu,
  • David O’Regan,
  • Robert Leech,
  • Peter J. Goadsby,
  • Ivana Rosenzweig

摘要

Sleep onset is an unstable transition whose microstructure may distinguish clinical phenotypes. Using Hori 4-second microstaging in patients with narcolepsy type 1, idiopathic REM sleep behaviour disorder, NREM parasomnia and an exploratory fibromyalgia cohort, each with matched controls (n = 48 pairs), we quantified timing, entropy, hemispheric laterality and sequence ordering. Narcolepsy showed compressed, irregular onset, fibromyalgia prolonged divergent onset, and the remaining groups near-normative trajectories, suggesting disorder-specific signatures of arousal instability.