Scholarlink

<p><i>Capsaspora owczarzaki</i> is a protist that may both reveal aspects of animal evolution and curtail the spread of schistosomiasis. <i>Capsaspora</i> exhibits a regulated aggregative behavior reminiscent of cellular aggregation in some animals—a process that might have contributed to the origin of animals. This aggregative behavior may also be vital for <i>Capsaspora</i> to colonize the intermediate host of parasitic schistosomes and potentially prevent the spread of schistosomiasis. Both applications demand elucidation of the mechanisms underlying <i>Capsaspora</i> aggregation. Toward this goal, we evaluated the chemical properties of lipid cues that activate aggregation. We found that a range of zwitterionic lipids induced this behavior, revealing that aggregation is activated by diverse lipid-rich conditions. Furthermore, we demonstrated that aggregation in <i>Capsaspora</i> requires clathrin-mediated endocytosis, highlighting the potential significance of endocytosis-linked cellular signaling in recent animal ancestors. Finally, we found that aggregation is initiated independently of protein translation, suggesting post-translational activation of filopodial retraction. Together, our findings illuminate the molecular and cellular basis of <i>Capsaspora</i>’s aggregative behavior, with implications for the evolution of animal multicellularity and the transmission of parasites.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Endocytosed lipids induce cell aggregation via filopodia retraction in a close relative of animals

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月7日

查看全文
  • Ria Q Kidner,
  • Eleanor B Goldstone,
  • Henry J Rodefeld,
  • Lorin P Brokaw,
  • Aria M Gonzalez,
  • Lalitha Sastry,
  • Ranojoy Baisya,
  • Núria Ros-Rocher,
  • Joseph P Gerdt

摘要

Capsaspora owczarzaki is a protist that may both reveal aspects of animal evolution and curtail the spread of schistosomiasis. Capsaspora exhibits a regulated aggregative behavior reminiscent of cellular aggregation in some animals—a process that might have contributed to the origin of animals. This aggregative behavior may also be vital for Capsaspora to colonize the intermediate host of parasitic schistosomes and potentially prevent the spread of schistosomiasis. Both applications demand elucidation of the mechanisms underlying Capsaspora aggregation. Toward this goal, we evaluated the chemical properties of lipid cues that activate aggregation. We found that a range of zwitterionic lipids induced this behavior, revealing that aggregation is activated by diverse lipid-rich conditions. Furthermore, we demonstrated that aggregation in Capsaspora requires clathrin-mediated endocytosis, highlighting the potential significance of endocytosis-linked cellular signaling in recent animal ancestors. Finally, we found that aggregation is initiated independently of protein translation, suggesting post-translational activation of filopodial retraction. Together, our findings illuminate the molecular and cellular basis of Capsaspora’s aggregative behavior, with implications for the evolution of animal multicellularity and the transmission of parasites.