<p>Permafrost degradation poses a serious threat to communities located in the Himalayan region. It can cause land subsidence and mass movements, damaging or destroying infrastructure downstream. In the current study, a high-resolution permafrost probability index based on machine learning was generated for the Kinnaur district in Himachal Pradesh, located in the western Himalayan region. Machine learning methods, including random forest, support vector machine, logistic regression, and artificial neural network, were trained on spatially distributed mean atmospheric air temperature, potential incoming solar radiation, elevation, slope, and aspect as predictive variables and intact rock glaciers as the target variable. Degrading permafrost zones and the overlaying glacial lakes were identified using the current zero-degree isotherm. The random forest technique provided the best results with an accuracy score of 89.43%. Scenario-based process chain models of glacial lake outburst floods (GLOFs) were modeled using r.avaflow and HEC-RAS for the Kashang glacial lake, which was identified as very highly hazardous. The lake volume was estimated to be 8.6 × 10⁶m³ by extrapolating the contours from overdeepening of the main glacier. Three sources of avalanches were identified based on permafrost degradation and slopes greater than 30°. The modeling results revealed that the potential GLOF can cause a peak discharge of 16,167 m³ s⁻¹, and floodwater can reach Kashang, where a hydropower is located, within 16 min in the high-magnitude scenario. The findings can provide important insights into GLOF hazard mitigation in the valley and serve as preliminary data for various stakeholders working to mitigate glacier-related hazards.</p>