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<p>Altered metabolism and perfusion are hallmarks of numerous diseases, yet simultaneous evaluations in vivo remain limited. We present a dual-purpose hyperpolarized probe combining [1-¹³C]pyruvate and ¹³C-<i>tert</i>-butyl alcohol (<sup>13</sup>C-TBA) for concurrent metabolic and perfusion imaging. An optimized formulation produced high polarizations with short build-up times. In vivo imaging in healthy and tumor-bearing rats demonstrated robust signals of TBA and pyruvate metabolism. This co-polarized dual probe offers strong preclinical and translational potential.</p>

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Feasibility of co-polarizing ¹³C-pyruvate and ¹³C-tert-butanol for simultaneous metabolic and perfusion imaging

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月18日

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  • Karen Dos Santos,
  • Samuel R Calos,
  • Qianhui Dou,
  • Atsushi M. Takahashi,
  • Leo L. Tsai,
  • Aaron K. Grant,
  • Yi-Fen Yen

摘要

Altered metabolism and perfusion are hallmarks of numerous diseases, yet simultaneous evaluations in vivo remain limited. We present a dual-purpose hyperpolarized probe combining [1-¹³C]pyruvate and ¹³C-tert-butyl alcohol (13C-TBA) for concurrent metabolic and perfusion imaging. An optimized formulation produced high polarizations with short build-up times. In vivo imaging in healthy and tumor-bearing rats demonstrated robust signals of TBA and pyruvate metabolism. This co-polarized dual probe offers strong preclinical and translational potential.