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<p>Magnetic resonance microscopy (MRM) produces high spatial resolution proton images of biological tissues, plants, and porous media, revealing microstructural details and contrast unattainable by other means. A major challenge in MRM is the low signal-to-noise ratio at high spatial resolutions, as smaller voxels produce smaller MR signals. This necessitates the use of highly sensitive microcoils, high-performance gradient systems, and high magnetic fields. Here, we present a step-by-step prescription for fabricating a cost-effective, flexible microimaging probe system compatible with horizontal bore high-field MRI systems. We demonstrate performance at 15.2 T by acquiring high-resolution (15 μm isotropic voxels) images of ex vivo mouse spinal cord (gray matter SNR 38; 46 h scan) and hippocampus (SNR 67; 45 h scan), clearly resolving microstructural features. Shorter imaging times are possible using compressed sampling. The flexible probe design supports solenoid diameters ranging from &lt; 1 mm up to 10 mm in diameter, offering flexibility for imaging a variety of biological samples at high resolution.</p>

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A practical prescription for magnetic resonance microscopy in a horizontal bore magnet

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月26日

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  • Bibek Dhakal,
  • Benjamin M. Hardy,
  • Adam W. Anderson,
  • Mark D. Does,
  • Junzhong Xu,
  • John C. Gore

摘要

Magnetic resonance microscopy (MRM) produces high spatial resolution proton images of biological tissues, plants, and porous media, revealing microstructural details and contrast unattainable by other means. A major challenge in MRM is the low signal-to-noise ratio at high spatial resolutions, as smaller voxels produce smaller MR signals. This necessitates the use of highly sensitive microcoils, high-performance gradient systems, and high magnetic fields. Here, we present a step-by-step prescription for fabricating a cost-effective, flexible microimaging probe system compatible with horizontal bore high-field MRI systems. We demonstrate performance at 15.2 T by acquiring high-resolution (15 μm isotropic voxels) images of ex vivo mouse spinal cord (gray matter SNR 38; 46 h scan) and hippocampus (SNR 67; 45 h scan), clearly resolving microstructural features. Shorter imaging times are possible using compressed sampling. The flexible probe design supports solenoid diameters ranging from < 1 mm up to 10 mm in diameter, offering flexibility for imaging a variety of biological samples at high resolution.