Scholarlink

<p>The current diagnostic gold standard for metabolic dysfunction-associated steatohepatitis (MASH) requires invasive biopsy to assess steatosis, inflammation, and ballooning. While MRI-based proton density fat fraction (PDFF) and MR elastography address steatosis and fibrosis, non-invasive methods for evaluating hepatic inflammation remain lacking. This study developed a diffusion MRI (dMRI)-based MR cytometry technique to map liver cellular properties, including MRI-derived cell size (excluding fat content) and cell density. Validation through histology-driven simulations and ex vivo MRI of fixed human liver specimens demonstrated that stromal regions exhibit smaller MRI-derived cell sizes and higher cell densities than both normal and fatty tissues. An in vivo feasibility study, conducted on healthy subjects (<i>n</i> = 5) and MASH patients (<i>n</i> = 5) using a clinical 3 T MRI system, further showcased the potential of MR cytometry to characterize pathological changes in liver microstructure.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Noninvasive assessment of liver inflammation in metabolic dysfunction associated steatohepatitis using MR cytometry

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年5月3日

查看全文
  • Xiaoyu Jiang,
  • Mary Kay Washington,
  • Manhal J. Izzy,
  • Gracie Piantek,
  • Ming Lu,
  • Xinqiang Yan,
  • John C. Gore,
  • Junzhong Xu

摘要

The current diagnostic gold standard for metabolic dysfunction-associated steatohepatitis (MASH) requires invasive biopsy to assess steatosis, inflammation, and ballooning. While MRI-based proton density fat fraction (PDFF) and MR elastography address steatosis and fibrosis, non-invasive methods for evaluating hepatic inflammation remain lacking. This study developed a diffusion MRI (dMRI)-based MR cytometry technique to map liver cellular properties, including MRI-derived cell size (excluding fat content) and cell density. Validation through histology-driven simulations and ex vivo MRI of fixed human liver specimens demonstrated that stromal regions exhibit smaller MRI-derived cell sizes and higher cell densities than both normal and fatty tissues. An in vivo feasibility study, conducted on healthy subjects (n = 5) and MASH patients (n = 5) using a clinical 3 T MRI system, further showcased the potential of MR cytometry to characterize pathological changes in liver microstructure.