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<p>Pneumonia is a common infection in people suffering with Alzheimer’s disease, leading to delirium, critical illness or severe neurological decline, which may be due to an amplified response of the blood-brain barrier (BBB) to peripheral insult. We assess the response of the BBB to repeated <i>Streptococcus pneumoniae</i> lung infection in rat model of Alzheimer’s disease (TgF344-AD), at 13- and 18-months old, using dynamic contrast-enhanced (DCE) MRI and filter exchange imaging. Higher BBB water exchange rate is initially detected in infected TgF344-AD rats. BBB water exchange rates correlated with hippocampus aquaporin-4 water channel expression in infected animals. We detected no differences in BBB permeability to gadolinium contrast agent measured by DCE-MRI, confirmed by staining for tight junction proteins, occludin and claudin-5. These findings provide insight into the mechanisms of how peripheral inflammation impacts the BBB.</p>

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MRI detects blood-brain barrier alterations in a rat model of Alzheimer’s disease and lung infection

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月4日

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  • Yolanda Ohene,
  • William J. Morrey,
  • Elizabeth Powell,
  • Katherine F. Smethers,
  • Nadim Luka,
  • Kieron South,
  • Michael Berks,
  • Catherine B. Lawrence,
  • Geoff. J. M. Parker,
  • Laura M. Parkes,
  • Hervé Boutin,
  • Ben R. Dickie

摘要

Pneumonia is a common infection in people suffering with Alzheimer’s disease, leading to delirium, critical illness or severe neurological decline, which may be due to an amplified response of the blood-brain barrier (BBB) to peripheral insult. We assess the response of the BBB to repeated Streptococcus pneumoniae lung infection in rat model of Alzheimer’s disease (TgF344-AD), at 13- and 18-months old, using dynamic contrast-enhanced (DCE) MRI and filter exchange imaging. Higher BBB water exchange rate is initially detected in infected TgF344-AD rats. BBB water exchange rates correlated with hippocampus aquaporin-4 water channel expression in infected animals. We detected no differences in BBB permeability to gadolinium contrast agent measured by DCE-MRI, confirmed by staining for tight junction proteins, occludin and claudin-5. These findings provide insight into the mechanisms of how peripheral inflammation impacts the BBB.