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<p>Marburg virus (MARV) is a highly pathogenic zoonotic filovirus. The <i>Orthomarburgvirus marburgense</i> species includes MARV and Ravn virus (RAVV), which differs from MARV by 21% at the nucleotide level and 22% at the protein level. This review offers fresh discussions of the epidemiology, genetics and natural reservoir transmission of RAVV, summarizes experimental animal models, outlines current vaccine development and raises outstanding questions about RAVV life history, transmission and pathogenicity.</p>

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Revisiting Ravn virus as the lesser known orthomarburgvirus

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月17日

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  • Ivet A. Yordanova,
  • Joseph B. Prescott

摘要

Marburg virus (MARV) is a highly pathogenic zoonotic filovirus. The Orthomarburgvirus marburgense species includes MARV and Ravn virus (RAVV), which differs from MARV by 21% at the nucleotide level and 22% at the protein level. This review offers fresh discussions of the epidemiology, genetics and natural reservoir transmission of RAVV, summarizes experimental animal models, outlines current vaccine development and raises outstanding questions about RAVV life history, transmission and pathogenicity.