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<p>Rotavirus (RV) and norovirus (NoV) are enteric viruses responsible for acute gastroenteritis that require fucosylated histo-blood group antigens for infection in humans. How the interaction of these viruses with fucosylated glycans modulates infection is not well understood. Treatment of target cells with a bacterial α1,2 fucosidase enzyme reduced RV and NoV infection in vitro, but increased replication in vivo. Conversely, the fucosidase inhibitor 1-deoxyfuconojirimycin impaired viral replication in both models, highlighting the role of fucosidase activity in fucose-dependent enteric virus infection. This underscores the complexity of fucose interactions for these viruses and implicates fucosidase activity as a potential antiviral target for RV and NoV.</p>

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Fucose dependent rotavirus and norovirus require fucosidase activity for optimal replication

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月29日

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  • Nazaret Peña-Gil,
  • Nanci Santos-Ferreira,
  • Sonia Llanos-Villatoro,
  • Ana Melero,
  • Roberto Cárcamo-Calvo,
  • Sergi López-Navarro,
  • Cristina Santiso-Bellón,
  • Javier Buesa,
  • Vicente Monedero,
  • Maria J. Yebra,
  • Joana Rocha-Pereira,
  • Roberto Gozalbo-Rovira,
  • Jesús Rodríguez-Díaz

摘要

Rotavirus (RV) and norovirus (NoV) are enteric viruses responsible for acute gastroenteritis that require fucosylated histo-blood group antigens for infection in humans. How the interaction of these viruses with fucosylated glycans modulates infection is not well understood. Treatment of target cells with a bacterial α1,2 fucosidase enzyme reduced RV and NoV infection in vitro, but increased replication in vivo. Conversely, the fucosidase inhibitor 1-deoxyfuconojirimycin impaired viral replication in both models, highlighting the role of fucosidase activity in fucose-dependent enteric virus infection. This underscores the complexity of fucose interactions for these viruses and implicates fucosidase activity as a potential antiviral target for RV and NoV.