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Augmentation of Omicron BA.1 pathogenicity in hamsters using intratracheal inoculation

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2024年1月16日

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  • Julia R. Port,
  • Claude Kwe Yinda,
  • Claire Ruckel,
  • Jonathan E. Schulz,
  • Brian J. Smith,
  • Carl I. Shaia,
  • Vincent J. Munster

摘要

The Omicron BA.1 variant of SARS-CoV-2 displays an attenuated phenotype in the Syrian hamster after intranasal inoculation. This is characterized by reduced viral replication and lung pathology in the lower respiratory tract. Here, we report that intratracheal inoculation with Omicron BA.1 recovers the lower respiratory tract replication and pathogenicity as observed with other lineages.