Scholarlink

<p>The cervix is a vital component of pregnancy: it provides a protective barrier during the antepartum period and undergoes drastic remodeling to facilitate parturition. There is a wealth of research that studies cervical remodeling during late pregnancy and labor, but few studies investigate the cervix during the earliest weeks of gestation. This study focuses on biochemical changes that occur between the time just prior to conception and 6–8 weeks gestation by enrolling patients undergoing intrauterine insemination. In vivo Raman spectroscopy was utilized as a nondestructive tool to identify early biochemical changes within the cervix. The study found the early cervical remodeling included increased vascularity, decreased structural proteins, and decreased trivalent collagen cross-linking. This is the first study demonstrating the feasibility of using in vivo Raman spectroscopy to measure biochemical changes upon the transition to early pregnancy and indicates that cervical remodeling begins in the earliest stages of pregnancy.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

In vivo Raman spectroscopy reveals biochemical changes in the human cervix with pregnancy establishment

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年6月4日

查看全文
  • Emily E. Spurlin,
  • Katy Belcher,
  • Folaoluwashewa Shofu,
  • Jennifer A. E. Esteves,
  • Patricia T. Jimenez,
  • Christine M. O’Brien

摘要

The cervix is a vital component of pregnancy: it provides a protective barrier during the antepartum period and undergoes drastic remodeling to facilitate parturition. There is a wealth of research that studies cervical remodeling during late pregnancy and labor, but few studies investigate the cervix during the earliest weeks of gestation. This study focuses on biochemical changes that occur between the time just prior to conception and 6–8 weeks gestation by enrolling patients undergoing intrauterine insemination. In vivo Raman spectroscopy was utilized as a nondestructive tool to identify early biochemical changes within the cervix. The study found the early cervical remodeling included increased vascularity, decreased structural proteins, and decreased trivalent collagen cross-linking. This is the first study demonstrating the feasibility of using in vivo Raman spectroscopy to measure biochemical changes upon the transition to early pregnancy and indicates that cervical remodeling begins in the earliest stages of pregnancy.