<p>Female sexual response has historically been understudied. Using the female sexual function index (FSFI-6), this study estimated female sexual response and its associations with sociodemographic characteristics, self-reported health conditions, and logging of sex events. Participants included a large and demographically diverse sample of 2392 users of the Flo Health mobile application (app) in the United States. Participants scored higher on FSFI-6, suggesting higher sexual function, if they were actively trying to conceive, met the criteria for obesity (body mass index (BMI) ≥ 30 kg/m²), or engaged in higher-than-average in-app sex event logging. Conversely, being underweight (BMI &lt; 18.5 kg/m²), or reporting at least one of the queried health conditions, was associated with lower FSFI-6 scores. This study demonstrates that many individual factors are relevant to female sexual response and is the first to report a positive association between trying to conceive, obesity, and sexual event logging with female sexual function.</p>