<p>The Internet of Bodies (IoB), an extension of the Internet of Things, refers to the network connecting human bodies and Internet of Things objects for health and medical applications. Current IoB systems are limited by the physical separation of sensing from memory and computing, leading to high latency and energy consumption. In this Perspective, we discuss how organic electrochemical transistors (OECTs) can serve as core hardware to evolve the IoB into an intelligent network with integrated sensing–memory–computing capabilities. OECTs are suited for this role owing to their dual functionality as volatile sensors and non-volatile in-memory computing devices, alongside their biocompatibility. Three integration approaches — heterogeneous, homogeneous and merged integration — can be used for OECT-based integrated sensing–memory–computing hardware. Addressing key challenges in device stability, biosafety and auxiliary circuits will be crucial to unlocking the potential of intelligent IoB to revolutionize personalized health care, brain–computer interface and sophisticated swarm intelligence.</p>