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<p>Unlike biomarkers in biofluids, airborne biomarkers are dilute and difficult to trace. Detecting diverse airborne biomarkers with sufficient sensitivity typically relies on bulky and expensive equipment like mass spectrometers that remain inaccessible to the general population. Here we introduce airborne biomarker localization engine (ABLE), a simple, affordable and portable platform that can detect both non-volatile and volatile molecules and particulate biomarkers from open air in about 15 min. ABLE substantially improves the gas detection limits by converting dilute gases into droplets by water condensation, producing concentrated aqueous samples that can be easily tested by existing liquid-sensing platforms. Fundamental studies of multiphase condensation revealed unexpected stability in condensate-trapped biomarkers, making ABLE a reliable, accessible and high-performance system for open-air-based biosensing applications such as non-contact infant healthcare, pathogen detection in public spaces and food safety monitoring.</p><p></p>

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Airborne biomarker localization engine for open-air point-of-care detection

  • 期刊论文

  • 发表日期：

    2025年5月21日

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  • Jingcheng Ma,
  • Megan Laune,
  • Pengju Li,
  • Jing Lu,
  • Jiping Yue,
  • Yueyue Yu,
  • Yamin Mansur,
  • Amio P. D. Ritwik,
  • Sai P. Peri,
  • Jessica Cleary,
  • Kaitlyn Oliphant,
  • Zachary Kessler,
  • Erika C. Claud,
  • Bozhi Tian

摘要

Unlike biomarkers in biofluids, airborne biomarkers are dilute and difficult to trace. Detecting diverse airborne biomarkers with sufficient sensitivity typically relies on bulky and expensive equipment like mass spectrometers that remain inaccessible to the general population. Here we introduce airborne biomarker localization engine (ABLE), a simple, affordable and portable platform that can detect both non-volatile and volatile molecules and particulate biomarkers from open air in about 15 min. ABLE substantially improves the gas detection limits by converting dilute gases into droplets by water condensation, producing concentrated aqueous samples that can be easily tested by existing liquid-sensing platforms. Fundamental studies of multiphase condensation revealed unexpected stability in condensate-trapped biomarkers, making ABLE a reliable, accessible and high-performance system for open-air-based biosensing applications such as non-contact infant healthcare, pathogen detection in public spaces and food safety monitoring.