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<p>A growing number of older adults now live in cities, raising important questions about how different features of urban built environments influence brain and cognitive health. Here we examine whether living in well-interconnected neighborhoods impacts the structure of the hippocampus in older adults. We analyze structural brain imaging and residential environment data from over 500 community-dwelling older adults (&gt;70 years old) living in Sydney, with each participant having up to three repeated brain imaging assessments over a 6-year period. For each participant, we quantify neighborhood connectivity using the street intersection density within walkable network buffers surrounding their home and measure the volumes of the hippocampal head, body and tail. We find that older adults living in highly connected neighborhoods have a larger hippocampus tail, a brain area involved in spatial navigation. However, they also show a steeper decline in hippocampal tail volume over time, with a slight rebound beyond the age of 85. These results can help inform the design of age-friendly street networks that better support brain health.</p>

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Neighborhood street connectivity and hippocampus volume in older adults

  • 期刊论文

  • 发表日期：

    2026年3月10日

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  • Govinda R. Poudel,
  • Perminder S. Sachdev,
  • Maria V. Soloveva,
  • Miguel A. Molina,
  • Ralf-Dieter Schroers,
  • Wei Li,
  • Luke D. Knibbs,
  • Vibeke Sorensen Catts,
  • Kaarin J. Anstey,
  • Wei Wen,
  • Bin Jalaludin,
  • Henry Brodaty,
  • Ester Cerin

摘要

A growing number of older adults now live in cities, raising important questions about how different features of urban built environments influence brain and cognitive health. Here we examine whether living in well-interconnected neighborhoods impacts the structure of the hippocampus in older adults. We analyze structural brain imaging and residential environment data from over 500 community-dwelling older adults (>70 years old) living in Sydney, with each participant having up to three repeated brain imaging assessments over a 6-year period. For each participant, we quantify neighborhood connectivity using the street intersection density within walkable network buffers surrounding their home and measure the volumes of the hippocampal head, body and tail. We find that older adults living in highly connected neighborhoods have a larger hippocampus tail, a brain area involved in spatial navigation. However, they also show a steeper decline in hippocampal tail volume over time, with a slight rebound beyond the age of 85. These results can help inform the design of age-friendly street networks that better support brain health.