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Will the promise of translational neuropsychopharmacology research ever deliver? The lion’s roar; the kitten’s purr

  • Jacqueline F. McGinty,
  • Victoria Arango,
  • Kathleen T. Brady,
  • Sandra D. Comer,
  • Rita Z. Goldstein,
  • Eric J. Nestler,
  • William W. Stoops,
  • Michael A. Nader

摘要

The gap between neuropsychopharmacology research claims (the lion’s roar) and effective treatments for neuropsychiatric disorders (the kitten’s purr) persists. However, a pattern of purrs over time may be as important as a loud roar. This perspective pulls together diverse preclinical and clinical voices of major figures in the neuropsychopharmacology research field to address how inter-disciplinary scientific approaches progress from thinking about the brain and its disorders to testing novel hypotheses to implementing treatments that may improve brain health in individuals with neuropsychiatric disorders.