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<p>We address methodological considerations in evaluating risk-reducing mastectomy among young <i>BRCA</i> carriers with prior history of breast cancer, emphasizing time-dependent analysis, realistic assumptions on mortality and contralateral breast cancer risk, and appropriate confounder adjustment as ways to improve accuracy in survival outcome estimates.</p>

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Response to: Survival after risk-reducing mastectomy in young BRCA1 carriers with breast cancer

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年9月19日

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  • Virginia Delucchi,
  • Matteo Lambertini,
  • Eva Blondeaux

摘要

We address methodological considerations in evaluating risk-reducing mastectomy among young BRCA carriers with prior history of breast cancer, emphasizing time-dependent analysis, realistic assumptions on mortality and contralateral breast cancer risk, and appropriate confounder adjustment as ways to improve accuracy in survival outcome estimates.