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<p>Sensorimotor processing in the human brain is largely lateralized, with the corpus callosum integrating these processes into a unified experience. Following complete callosotomy, this integration breaks down, resulting in disconnection syndromes. We asked how much of the corpus callosum is sufficient to support functional unity—the absence of disconnection syndrome—by comparing three complete callosotomy patients with one retaining only the splenium. Using lateralized tasks across visual, tactile, visuospatial, and language domains, we predicted domain-specific deficits in the splenium-only patient based on established anatomical models of callosal topography. Strikingly, while complete callosotomy patients exhibited disconnection syndromes, the splenium patient demonstrated functional unity across all domains—as if his entire corpus callosum were intact. Our findings highlight the brain’s remarkable capacity to maintain behavioral integration through minimal preserved pathways, highlighting how the structure-dependent reorganizational capacity of the human brain may allow to preserve functional unity.</p>

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No disconnection syndrome after near-complete callosotomy

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月15日

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  • Selin Bekir,
  • Johanna L. Hopf,
  • Theresa Paul,
  • Valerie M. Wiemer,
  • Tyler Santander,
  • Henri E. Skinner,
  • Anna Rada,
  • Friedrich G. Woermann,
  • Thilo Kalbhenn,
  • Barry Giesbrecht,
  • Christian G. Bien,
  • Olaf Sporns,
  • Michael S. Gazzaniga,
  • Lukas J. Volz,
  • Michael B. Miller

摘要

Sensorimotor processing in the human brain is largely lateralized, with the corpus callosum integrating these processes into a unified experience. Following complete callosotomy, this integration breaks down, resulting in disconnection syndromes. We asked how much of the corpus callosum is sufficient to support functional unity—the absence of disconnection syndrome—by comparing three complete callosotomy patients with one retaining only the splenium. Using lateralized tasks across visual, tactile, visuospatial, and language domains, we predicted domain-specific deficits in the splenium-only patient based on established anatomical models of callosal topography. Strikingly, while complete callosotomy patients exhibited disconnection syndromes, the splenium patient demonstrated functional unity across all domains—as if his entire corpus callosum were intact. Our findings highlight the brain’s remarkable capacity to maintain behavioral integration through minimal preserved pathways, highlighting how the structure-dependent reorganizational capacity of the human brain may allow to preserve functional unity.