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<p>Antibiotic resistance is surging, demanding approaches that detect resistance before genetic fixation, since MIC, sequencing, and culture assays detect resistance late. We present Metabolomics-Driven Intervention Antibiotic Design (MDAD), which stages resistance evolution from metabolic compensation to sub-lethal adaptation to genetic fixation. A brief pulse challenge with a targeted metabolomics panel yields a pre-genetic risk index, interpreted with time-kill assays to situate early survival behaviours and guide mechanism-aware treatment and surveillance.</p>

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Metabolomics-driven prediction of antibiotic resistance: a perspective on pre-genetic intervention

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月16日

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  • Maytham Hussein,
  • Darren J. Creek,
  • Mark Baker,
  • Gauri G. Rao,
  • Jian Li,
  • Tony Velkov

摘要

Antibiotic resistance is surging, demanding approaches that detect resistance before genetic fixation, since MIC, sequencing, and culture assays detect resistance late. We present Metabolomics-Driven Intervention Antibiotic Design (MDAD), which stages resistance evolution from metabolic compensation to sub-lethal adaptation to genetic fixation. A brief pulse challenge with a targeted metabolomics panel yields a pre-genetic risk index, interpreted with time-kill assays to situate early survival behaviours and guide mechanism-aware treatment and surveillance.