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<p><i>Klebsiella pneumoniae</i> is one of the most important nosocomial pathogens worldwide. In Colombia, <i>K. pneumoniae</i> has been identified as the second most frequent microbial etiologic agent of healthcare-associated infections. We conducted a prospective local study of 335 <i>K. pneumoniae</i> isolates in 26 nationwide hospitals from 2020 to 2021. We found that the spread of carbapenem resistance was mediated by successful clones belonging to sequence types (ST) such as ST11, ST1082, and ST307, related to intra-hospital infections. We observed that <i>bla</i><sub><i>KPC</i></sub> remains the primary resistance mechanism to carbapenems and that, unlike other countries, ST11 strains commonly carry <i>bla</i><sub>KPC-3</sub>. We identified the recent introduction and circulation of new sequence types with different resistance mechanisms and hypervirulence. Besides, we detected possible transmission events closely linked to carbapenemase-carrying strains, mainly in intensive care units. This study helps us understand how <i>K. pneumoniae</i> disseminates in Colombian hospitals and where to direct effective intervention measures.</p>

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Epidemiological Genomics of Klebsiella pneumoniae isolates from hospitals across Colombia

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月21日

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  • Victor A. Medina,
  • Angela S. García-Vega,
  • Fernando Rodríguez,
  • Enmanuel S. Triviño-García,
  • Jaime A. Robledo,
  • Aura L. Leal,
  • Julián C. Galvis,
  • Luis F. Reyes,
  • Carlos Robledo,
  • Ana Maria Montoya,
  • Alba Mery Gómez Castañeda,
  • Adriana María García Muñoz,
  • Lisseth Pizano,
  • Marilú Patiño,
  • Santiago Atehortua,
  • Indira Berrio,
  • Laura Patricia Pérez,
  • Edisson Andrés Mira Castro,
  • Adriana Marín,
  • Carlos Álvarez Moreno,
  • Claudia Rocío Sierra-Parada,
  • Diego Josa Montero,
  • Julián A. Lozada,
  • Magda Sánchez López,
  • Nubia Montañez Montero,
  • German Camacho-Moreno,
  • Jorge Alberto Cortés,
  • Ana Yadira Santana,
  • Fernando Rosso,
  • Olga Lucia Agudelo Rojas,
  • Liliana Mazillo,
  • Marco Solarte,
  • Lorena Jaramillo,
  • Andrés F. Arias,
  • María Camila Flechas Alarcón,
  • Johan Sebastián Hernández Botero,
  • Iruka N. Okeke,
  • Natacha Couto,
  • Emmanuelle A. Kumaran,
  • Georgina Lewis-Woodhouse,
  • Silvia Argimon,
  • Stefany A. Arevalo,
  • Anthony P. Underwood,
  • Xavier Fargetton,
  • David M. Aanensen,
  • Maria P. Donado-Godoy

摘要

Klebsiella pneumoniae is one of the most important nosocomial pathogens worldwide. In Colombia, K. pneumoniae has been identified as the second most frequent microbial etiologic agent of healthcare-associated infections. We conducted a prospective local study of 335 K. pneumoniae isolates in 26 nationwide hospitals from 2020 to 2021. We found that the spread of carbapenem resistance was mediated by successful clones belonging to sequence types (ST) such as ST11, ST1082, and ST307, related to intra-hospital infections. We observed that blaKPC remains the primary resistance mechanism to carbapenems and that, unlike other countries, ST11 strains commonly carry blaKPC-3. We identified the recent introduction and circulation of new sequence types with different resistance mechanisms and hypervirulence. Besides, we detected possible transmission events closely linked to carbapenemase-carrying strains, mainly in intensive care units. This study helps us understand how K. pneumoniae disseminates in Colombian hospitals and where to direct effective intervention measures.